PixelPeeper allows you to watch a pixel on your screen and execute an AppleScript when it sees that pixel change. This can be used to alert you when a long operation is complete. For example, you can watch a pixel within the progress bar/window when performing a software update or installation, downloading or copying large files, or backing up your system. There are literally hundreds of other uses - please let us know how you put PixelPeeper to work watching your desktop.
To use PixelPeeper, simply edit the AppleScript to choose your preferred alert - an audible signal, email, or other notification - then click to select a pixel to watch. When it sees that pixel change, the AppleScript runs and you receive your alert.
See PixelPeeper in action: vimeo.com/68527599